The new recruit joins from UK pubcaster the BBC, starting next month.
In 14 years at the UK pubcaster she has been a researcher, a producer, and most recently, an assistant commissioner in the comedy department, working across TV and radio.
At pay TV broadcaster Sky she will commission and exec produce comedy fare for the pay TV operator, working across its Sky1, Sky Atlantic, and Sky Arts channels.
She said: “Sky has a great reputation for comedy. I’m looking forward to making my mark with excellent new shows whilst achieving Sky’s ambition to provide outstanding content for viewers.”
There have been changes in Sky’s comedy team in the wake of former chief Lucy Lumsden’s departure to set up her own indie, Yellow Door Productions.
She was replaced by Jon Mountague, who is Sky’s head of comedy commissioning.
Speaking about Ghelani’s hire, he said: “We’re committed to providing customers with the very best in British comedy alongside our laugh-out-loud US shows like Modern Family and Silicon Valley. I’m sure Tilusha will help us cement our place as the home of the very best comedy available anywhere.”