Daniels takes on the post having previously been Discovery Channel’s executive VP, production and development.
She will now oversee programming, production, development, new media and marketing at TLC and report to Eileen O’Neill, group president, Discovery and TLC Networks.
The news comes after Amy Winter stepped down from the GM role last month.
“Nancy is a talented creative executive, a motivating team leader, and a risk-taking problem solver, with a track record of success that makes her a perfect fit to lead the TLC brand forward,” said O’Neill.
“Her previous success at TLC, combined with her leadership roles at both Discovery Channel and Discovery Fit & Health, gives her the ability to jump right in and continue TLC’s growth and pop culture domination.”