The soapy summer season scripted series will not return for a fifth run following a lower fourth season ratings.
It has sold internationally to likes of TLC in the UK, where it was a launch title in 2013.
Mistresses is a coproduction of Good Talk Productions, Bob Sertner Productions, ABC Studios, Tsiporah Productions and Ecosse Films, the latter of which created the British show on which the series was based.
The UK show ran on BBC One between 2008 and 2010, comprising 16 episodes and three seasons.
Before ABC greenlit a formatted version, Lifetime had attempted a remake and produced a pilot in 2009.
The series follows four female characters and their complex and often illicit relationships.
In further news from the States, FX has cancelled Sex&Drugs&Rock&Roll after two seasons. It comes from Leary-owned prodco Apostle, Fox 21 Television Studios and FXP.
The comedy, created by and starring Denis Leary, follows the lead singer from a promising late eighties rock band attempting to recapture former glories.