Topping will join Microsoft from Channel 4, where she is business manager of the UK commercial broadcaster’s online division.
During a seven-year stint at Channel 4 Topping oversaw the launch of catch-up service 4oD and relaunch of channel4.com.
At Microsoft she will be business manager of the games company’s London unit Soho Productions.
She will report to Soho Productions’ studio manager Brian Stone and is due to join the company in early August.
Prior to Channel 4 Topping was a journalist at UK pubcaster the BBC. She was recently elected incoming vice chair of the British Interactive Media Association (BIMA).
She said: ” This is such an exciting time to be joining Microsoft with the launch of Xbox One as the new generation all-in-one home entertainment system. I’m looking forward to being part of the team building amazing TV content experiences for Xbox’s millions of users.”